Map & Directions
Corporate Office
Onyx Pharmaceuticals, Inc.
2100 Powell Street
Emeryville, CA 94608
P: 510.597.6500
F: 510.597.6600
Information Request
- Directions from San Francisco International Airport/Southwest of Emeryville
- Directions from Oakland International Airport/South of Emeryville
- Directions from San Francisco / West of Emeryville
- Directions from Sacramento/North of Emeryville
- Directions from Walnut Creek area / East of Emeryville

From San Francisco International Airport/Southwest of Emeryville
- Take Highway 101 North to Interstate-80 East. Cross the Bay Bridge and stay to the left
- Take Interstate-80 East toward Berkeley/Sacramento
- Take the first exit off Interstate-80 East at Powell Street
- Turn left onto Powell Street, drive under the freeway and get into the 2nd lane from the right which curves onto Frontage Road
- Take first left at the light (note there is no street sign)
- Take first left into 2100 Powell Street parking entrance
From Oakland International Airport/South of Emeryville
- Follow Airport Drive to Hegenberger Road
- Turn right onto Hegenberger Road, stay in the far right lane
- On the right-hand side, merge onto 880 North towards Downtown Oakland
- Take the Interstate-980 East/CA-24 Walnut Creek exit
- Take the Interstate-580 San Francisco/Hayward ramp on the right hand side
- Veer to the left onto Interstate-580 West towards San Francisco
- Get into the right hand lanes to take Interstate-580 West/Interstate-80 East towards Berkeley/Sacramento
- Take the first exit off Interstate-80 East at Powell Street
- Turn left onto Powell Street, drive under the freeway and get into the 2nd lane from the right which curves onto Frontage Road
- Take first left at the light (note there is no street sign)
- Take first left into 2100 Powell Street parking entrance
If You Missed the Powell Street Exit:
- Take the Ashby - Highway 13/Shellmound Street Exit and veer right onto Shellmound Street Exit
- Turn right onto Shellmound Street
- Turn right onto Shellmound WAY, stay in right lane
- Turn left onto Christie Street, get into right lane immediately
- Take first right onto Powell Street
- Drive under the freeway and get into 2nd lane from right (curves to the right onto Frontage Road)
- Take first left at the light (note there is no street sign)
- Take first left into 2100 Powell Street parking entrance
From San Francisco / West of Emeryville
- Take Interstate-80 East across the Bay Bridge and stay to the left
- Take Interstate-80 East toward Berkeley/Sacramento
- Take the first exit off Interstate-80 East at Powell Street
- Turn left onto Powell Street, drive under the freeway and get into the 2nd lane from the right which curves onto Frontage Road
- Take first left at the light (note there is no street sign)
- Take first left into 2100 Powell Street parking entrance
From Sacramento/North of Emeryville
- Take Interstate-80 West toward San Francisco
- Take the Powell Street exit
- At the light, go straight through intersection (keep to the right of 2100 Powell Street, also known as Watergate Office Tower IV)
- Take the first left into the 2100 Powell Street parking entrance
From Walnut Creek area / East of Emeryville
- Take Highway 24 West toward Oakland/San Francisco
- After leaving the Caldecott Tunnel, stay in the right lanes
- Take San Francisco/Hayward/Interstate-580 West Exit
- Take Interstate-580 West - Berkeley/Interstate-80 East - Sacramento Exit. Stay in right lane
- Take first exit off Interstate-80 East at Powell Street
- Turn left onto Powell Street, drive under the freeway and get into the 2nd lane from the right which curves onto Frontage Road
- Take first left at the light (note there is no street sign)
- Take first left into 2100 Powell Street parking entrance
